Screeninc is a national infrastructure that enables large scale functional genomic screening in the Netherlands. ScreeninC provide clinical and basic research groups access to unique research tools allowing them to expand their ongoing research programs and to initiate new research projects. It will provide expertise, tools and infrastructure to apply functional genomic technologies from advanced model generation to large scale screening. The broad scope and combination of these technologies will advance our understanding of cancer biology leading to the discovery of novel therapeutic strategies. In addition, results from these efforts will lead to the discovery of biomarkers, effective combination therapies and strategies to revert treatment resistance. As result, this initiative will facilitate improved therapies for cancer patients.
CRISPR Screen technology
CRISPR-KO, CRISPR-I, CRISPR-A
High content imaging
The ScreeninC initiative is composed of three “core” groups located at Leiden Academic Centre for Drug Research (LACDR) / Leiden University(Prof. Dr. Bob van de Water), European Research Institute for the Biology of Ageing (ERIBA)/ University Medical Center Groningen (Dr. Floris Foijer) and The Netherlands Cancer Institute (Dr. Roderick L Beijersbergen). Each of these core groups is directly linked to genome editing and screening infrastructures; The iPSC/CRISPR centre (Foijer), the Leiden Cell Observatory High Content Imaging Screening Facility (van de Water) and the NKI Robotics and Screening Center (Beijersbergen). Each core group brings unique state-of-the-art technological platforms that are complementary.
The NKI Robotics and Screening Center
he Netherlands Cancer Institute
Dr. Roderick L Beijersbergen
The Leiden Cell Observatory High Content Imaging Screening Facility
Leiden Academic Centre for Drug Research LACDR Leiden University
Prof. Dr. Bob van de Water
The iPSC/CRISPR Centre
European Research Institute for the Biology of Ageing (ERIBA)/ University Medical Center Groningen
Dr. Floris Foijer
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